Pill splitting: which ones are safe to divide?

4 Dec

by Carolyn Thomas    @HeartSisters

Physicians and other prescribers are often frustrated by their non-compliant patients. (Full disclosure: as I’ve written about here and here, even the word non-compliant makes me cranky, as it sounds so much like it has punishment at the end of it). These frustrating patients are generally described as those who are not following doctor’s orders (there’s another patronizing term for you) or more specifically, are not taking the medications prescribed for them.

A Consumer Reports Health prescription drugs survey reported that many people are splitting their pills in half to save money on high-priced prescription drugs. The bad news, however, is that many have also learned to save even more money by taking half-doses of half-a-pill every other day.

But here’s a consumer-friendly example of pill-splitting that makes sense:

“A bottle of 30 x 100mg pills might cost almost the same as a bottle of 30 x 50mg pills. Cutting the 100mg pills in half could indeed cut your medication bill, but there’s a right way and a wrong way to split pills.”

You can ask your pharmacist to cut pills in half for you. But if you’re considering splitting your pills, these tips from the Consumer Reports Health free pill splitting guide will help make sure that you do it the right way, as the survey report suggests:

Look for this kind of pill splitter

Look for this kind of pill splitter ($3-10)

“First, ask your doctor or pharmacist whether your medication can be safely split. Some medications should not be split (more on that below), but in general, many common ones can, including aspirin, cholesterol-lowering drugs known as statins, and many high blood pressure and depression drugs. Find out which pills are okay to split – and which ones are not.  And always use a pill splitter to ensure you’ve split the medication into equal halves. Pill splitters are widely available from pharmacies.

Don’t split your pills with a knife. Studies show that doing so too often leads to unequal halves. Pills should only be split in half, not into smaller portions, such as thirds or quarters. The easiest pills to split are relatively flat round ones with a scored center, a slightly indented line that runs across the center of the pill. However, not every pill that has a scored center is meant to be split.

Don’t split your pills in advance. Some pills may deteriorate when exposed to air and moisture for long periods after being split. So for medications taken on a regular basis, split your pill only on the day you take the first half, and then take the other half on the second day or whenever you are scheduled to take your next dose.

“If your doctor has prescribed half tablets, your pharmacy may split the pills for you. So when you pick up the prescription or a refill, ask if the pills have been split so you don’t inadvertently split them again. Also be aware that the prescription label may refer to “one tablet” even though your doctor has told you to split the pills. If you’re not sure about the label instructions or your doctor’s instructions, check with your physician and your pharmacist before splitting or taking your medication.

“There is no official or complete list of medicines that can be split. And it can actually be dangerous to split some drugs. Generally, the following kinds of pills should not be split:

  • Chemotherapy drugs
  • Anti-seizure medicines
  • Birth control pills
  • Blood thinners (Coumadin, warfarin)
  • Capsules of any kind that contain powders or gels
  • Pills with a hard outside coating
  • Time-release pills designed to release medication over time in your body
  • Pills that are coated to protect your stomach (enteric coating)
  • Pills that crumble easily, irritate your mouth, taste bitter, or contain strong dyes that could stain your teeth and your mouth.
  • Combination tablets that contain two or more medicines, in which the amount of one active ingredient changes from one tablet size to the next, but the amount of the other does not. (You’ll have to ask your doctor or pharmacist.) Here are some examples:
  • amlodipine/atorvastatin (Caduet)
  • amlodipine/olmesartan (Azor),
  • amoxicillin/clavulanic acid (Augmentin, and others),
  • ezetemibe/simvastatin (Vytorin),
  • irbesartan/hydrochlorothiazide (Avalide)
  • oxycodone/acetaminophen (Percocet, and others)
  • sitagliptin/metformin (Janumet)

“Some pills that can be split (but always check with your doctor or pharmacist beforehand; your situation may require something different):

  • amlodipine (Norvasc)
  • atorvastatin (Lipitor)
  • citalopram (Celexa)
  • doxazosin (Cardura)
  • finasteride (Proscar) NOTE: Women should NOT handle crushed or broken finasteride tablets if pregnant or possibly pregnant. Broken tablets lose some of the protective outer coating, thus allowing absorption of finasteride through the skin. The drug may cause birth defects.
  • levothyroxine (Synthroid)
  • lisinopril (Zestril)
  • lovastatin (Mevacor)
  • paroxetine (Paxil)
  • quinapril (Accupril)
  • sertraline (Zoloft)
  • simvastatin (Zocor)
  • tadalafil (Cialis)
  • vardenafil (Levitra)

IMPORTANT!  Talk to your physician or your pharmacist for specific advice on which pills can be safely split.

© Consumer Reports Health, Steve Mitchell, Associate Editor

Q: Do you split any of your pills?

NOTE FROM CAROLYN: I wrote much more about our cardiac meds (and other issues!) in my book A Woman’s Guide to Living with Heart Disease (Johns Hopkins University Press, 2017). You can ask for this book at your local bookshop, or order it online (paperback, hardcover or e-book) at Amazon, or order it directly from Johns Hopkins University Press (use their code HTWN to save 20% off the list price when you order).

See also:

23 Responses to “Pill splitting: which ones are safe to divide?”

  1. Roy Conol Ong June 11, 2019 at 5:45 am #

    Can I split VYMADA 100mg? The pharmacist said yes.

    Like

    • Carolyn Thomas June 11, 2019 at 1:23 pm #

      I don’t know, Roy. I’m not a doctor. If your pharmacist (AND your doctor) say yes, that’s probably a safe bet, but please don’t split anything until you double-check with your doc, especially if you’re splitting your pills to deliberately take less of that medication.

      Like

  2. Patty Staton March 18, 2019 at 5:45 am #

    Can hydrocodone 7.5 be split?

    Like

    • Carolyn Thomas March 19, 2019 at 6:33 am #

      I don’t know, Patty. Hydrocodone is an opioid that requires careful tapering when weaning off the drug. More info here about tapering off.

      See your physician before you cut anything in half!

      Like

  3. Schyler March 29, 2018 at 7:18 am #

    Can you split 10 mg toroadol pills?

    Like

    • Carolyn Thomas March 30, 2018 at 5:22 am #

      I’m guessing you mean toradol. Ask the pharmacist, or the physician who prescribed them, if you can split them safely.

      Like

  4. Larry Tay May 19, 2017 at 11:36 pm #

    Thank you for your very useful article on pill splitting. You advised against splitting Janumet pills but what about Januvia pills? Please advise, thank you.

    Like

    • Carolyn Thomas May 20, 2017 at 3:12 pm #

      Hi Larry,

      I’m neither a physician nor a pharmacist, but my best guess is that Januvia has one active ingredient (sitagliptin) while Janumet is one of those combination drugs listed (sitagliptin and metformin) on the Consumer Reports ‘no-no’ list. Double check with your pharmacist just to make sure.

      Like

      • Larry Tay May 20, 2017 at 4:46 pm #

        Thank you Carolyn for your quick reply.
        Both my doctor as well as the pharmacist say it’s okay to split the pill , however FDA reports say it should not be split, crushed or chewed.
        I was hoping you could clear up the confusion and am still hopeful,
        Best regards
        Larry Tay

        Like

        • Carolyn Thomas May 20, 2017 at 6:31 pm #

          Well, we seem to have dueling experts at work here, don’t we? The FDA does indeed say that (but I wonder if they include that disclaimer for all drugs, or perhaps – unlikely – because it’s a film-coated pill?) The manufacturer’s (Merck) site doesn’t contain that warning. You might want to contact them directly. Again, I’m no expert so you’ll have to decide who to trust!

          Like

          • Larry Tay May 20, 2017 at 7:04 pm #

            Thanks again Carolyn for your Super quick response.
            I did contact the local branch of Merck ( they have both offices and manufacturing plants here in Singapore) even before I checked with the FDA, but they refused to comment which to me is both irresponsible as well as strange.

            Like

  5. Will Henss December 22, 2016 at 7:45 pm #

    This is a very helpful guide Carolyn! Some people might be doing self-medication and thinking that generally, pills can be cut into halves. Good thing is that you have come up with a helpful list which pills can’t be cut into halves. At least now, more readers are aware of that kind of situation. Thank you for sharing!

    Liked by 1 person

    • Carolyn Thomas December 22, 2016 at 7:49 pm #

      Thanks for your comment, Will!

      Like

    • Annette Stolz March 23, 2019 at 5:05 pm #

      I am trying to find out specifically if you can split a tylenol #4 in half, and I have been searching and not one website has said whether I can or cant!

      Like

      • Carolyn Thomas March 23, 2019 at 11:06 pm #

        Annette, that is a sign that you should ask your physician directly if this is a good idea or not.

        Like

  6. Jenn December 6, 2016 at 6:39 pm #

    Since my tricuspid valve was replaced 5 years ago, I’ve been taking 1/4 of the smallest available dose of a beta blocker. I used a pill splitter for years, never getting neat 1/4s, so trying to alternate days of big pieces with days of small pieces. This year I finally asked the pharmacy to cut them for me. They don’t do any better than I ever did, but it has saved me a lot of fiddling. Yesterday, the cardiologist told me I can stop taking that medication. Hooray!

    Like

    • Carolyn Thomas December 6, 2016 at 7:13 pm #

      Hi Jenn – fiddling with 1/4 of a small pill is a whole different experience – even for the experts, right? It’s a good thing you can just stop taking your beta blockers now, because reducing the fractions any more would mean just a pile of little crumbs.

      Like

  7. Kathleen December 4, 2016 at 9:54 pm #

    Even with a pill splitter I find halves are not quite equal, but usually close enough. Thanks for this news to me: That advance split meds might actually deteriorate. I usually take a certain med at half dose and have been merrily splitting an entire bottle when it arrives.

    Liked by 1 person

    • Carolyn Thomas December 5, 2016 at 4:15 am #

      I know – I used to do that too! Those halves might not be 100% equal but they are sure better than ending up with one good part and one fractured into four tiny chunks by the kitchen knife I used to use. Thanks, Kathleen…

      Like

  8. Dr. Anthony Pearson December 4, 2016 at 10:30 am #

    I joined the pill-splitters a few years ago and heartily embraced the practice. More here.

    Liked by 1 person

    • Carolyn Thomas December 4, 2016 at 11:14 am #

      That’s a great article, Dr. P. I never thought of buying a pill splitter before now as being an “entry into the geriatric fraternity”! 🙂

      Like

  9. Barb December 4, 2016 at 5:22 am #

    What a wonderful ‘reminder’ article on pill splitting. I take the lowest dose of a drug with the pill split in half and can still feel the effects if I don’t take it. Our hearts are so sensitive to any chemical change I can easily see that an unevenly split pill could have some unexpected results, i.e. blood pressure going too low.

    Thanks for keeping us heart smart, Carolyn!

    Liked by 1 person

    • Carolyn Thomas December 4, 2016 at 5:30 am #

      Hello Barb – I cringe now when I think of the many “unevenly split” pills I’ve hacked in half with a kitchen knife before I got my pill splitter.

      Like

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